Is lxazomib less effective than bortezomib?

Ixazomib (Ixazomib) and bortezomib (Bortezomib) are both drugs used to treat multiple myeloma (Multiple Myeloma). The comparison of their efficacy needs to be evaluated based on clinical studies and the specific conditions of the patients. Here are some general comparisons about the two drugs:

Bortezomib’s long-term application history: Bortezomib is a pioneer drug in the treatment of multiple myeloma. It has been used clinically for many years and has accumulated a large amount of clinical experience. It interferes with the growth and reproduction of cancer cells by inhibiting the function of the proteasome and is widely regarded as an effective treatment.

Oral administration of ixazomib: Ixazomib is relatively new and has the convenience of oral administration. Compared with the injection administration of bortezomib, it is more convenient for patients. This enables patients to self-administer medications at home without having to travel to the hospital each time.

Effectiveness depends on individual circumstances: Which drug is more effective depends on the patient's specific circumstances, including age, health, disease stage, genetic factors, etc. Doctors often use these factors to develop an individualized treatment plan.

Combination treatment options: Often, both ixazomib and bortezomib are used with other medications, such as immunomodulators and hormones, to increase the effectiveness of the treatment. Therefore, when comparing the efficacy of these two drugs, the overall treatment regimen needs to be considered.

Clinical trial data: Clinical trials have shown that combination therapy with ixazomib and other drugs has achieved significant results in the treatment of multiple myeloma patients, including extending survival, improving quality of life, and reducing symptoms. However, this does not mean that it is superior to bortezomib in all circumstances.

The original drug of Ixazomib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, but the price is still relatively high. The price is about 15,000 to 6,000 yuan. For specific prices and medical insurance reimbursement policies, please consult the local hospital pharmacy or medical insurance bureau. Foreign original drugs are even more expensive. The cheaper foreign ones are ixazomib generics, mainly Laotian generics. The price is more than 1,000 yuan, and the ingredients of the original drugs and generic drugs are basically the same.