What are the adverse reactions of lxazomib?

Ixazomib (Ixazomib) is a drug used to treat multiple myeloma (Multiple Myeloma) and belongs to the proteasome inhibitor class. Although ixazomib can effectively control the growth and reproduction of cancer cells, it may also cause some adverse reactions. Patients and physicians should pay close attention to these potential side effects so that appropriate steps can be taken to manage and alleviate these discomforts. The following are some common adverse reactions of ixazomib:

1. Nausea and vomiting: Nausea and vomiting are one of the common side effects of ixazomib. These symptoms usually appear within the first few days after treatment begins and gradually decrease as treatment continues. Doctors can prescribe medications to relieve these discomforts or recommend dietary and lifestyle changes to reduce nausea and vomiting.

2. Diarrhea: Diarrhea is also one of the common adverse reactions of ixazomib. Patients may experience abdominal discomfort, diarrhea, and intestinal discomfort. Maintaining adequate fluid intake and following your doctor's recommendations can help manage diarrhea.

3. Fatigue: Fatigue is one of the common symptoms in patients with multiple myeloma, and this feeling may be aggravated during ixazomib treatment. Patients should pay attention to a balance of rest and exercise and seek medical advice when needed.

4. Anemia: Ixazomib may cause anemia, which is an insufficient number of red blood cells in the blood. Anemia can cause symptoms such as fatigue, dizziness, and shortness of breath. Doctors may recommend that patients receive erythropoiesis-stimulating factor therapy or other supplements.

5. Low platelet count: Ixazomib can also sometimes cause a decrease in platelets, which may increase the risk of bleeding and congestion. Patients should avoid injury, reduce the risk of bleeding, and have regular blood tests to monitor platelet counts.

6. Infections: Because ixazomib may affect the function of the immune system, patients may be more susceptible to infections. Patients should follow their doctor's advice, take infection prevention measures, and pay close attention to any signs of infection, such as fever, sore throat, cough, etc.

7. Respiratory symptoms: Some patients may experience respiratory-related discomfort, such as sore throat, cough, or shortness of breath. These symptoms usually require evaluation and treatment by a doctor.

8. Bone pain: Patients with multiple myeloma are often accompanied by bone pain, and treatment with ixazomib may affect bones. Your doctor may recommend appropriate pain relief treatment to relieve these pains.

9. Peripheral neuropathy: Peripheral neuropathy is a side effect of bortezomib (another multiple myeloma treatment), while ixazomib may cause relatively low neurotoxicity. However, patients should still undergo regular neurological examinations to monitor for any potential neurological problems.

10. Skin reactions: During treatment with ixazomib, patients may experience skin reactions, such as rash or itching. These reactions are usually mild but need to be reported to your doctor to ensure prompt treatment.

It should be emphasized that the above adverse reactions may not occur in every patient, and the severity may vary depending on individual patients. During treatment with ixazomib, patients should closely follow their doctor's advice and promptly report any discomfort or suspected side effects to the medical team. Doctors will take appropriate measures to manage adverse reactions based on the patient's specific situation to ensure the safety and effectiveness of treatment. During the treatment period, the doctor will regularly monitor the patient's condition, conduct necessary examinations and adjust the treatment plan.

The original drug of Ixazomib has been launched in China and has been included in medical insurance. Patients can purchase it domestically, but the price is still relatively high. The price is about 15,000 to 6,000 yuan. For specific prices and medical insurance reimbursement policies, please consult the local hospital pharmacy or medical insurance bureau. Foreign original drugs are even more expensive. The cheaper foreign ones are ixazomib generics, mainly Laotian generics. The price is more than 1,000 yuan, and the ingredients of the original drugs and generic drugs are basically the same.