What are the side effects of Pazopanib?

In clinical studies of pazopanib in the treatment of renal cell carcinoma, the most common adverse reactions (≥20%) were diarrhea, hypertension, hair color changes, nausea, fatigue, anorexia, and vomiting. In clinical studies of soft tissue sarcoma, common adverse reactions (≥20%) were fatigue, diarrhea, nausea, weight loss, hypertension, decreased appetite, vomiting, tumor pain, hair color changes, musculoskeletal pain, headache, dysgeusia, dyspnea, and skin hypopigmentation.

Post-marketing adverse reactions of pazopanib include polycythemia, retinal detachment/tear, pancreatitis, tumor lysis syndrome, arterial (including aorta) aneurysm, dissection and rupture. Pazopanib should not be used in people who are allergic to pazopanib or any other ingredient. Serious and fatal hepatotoxicity has also been observed with pazopanib in clinical trials. Patients should promptly monitor liver function and interrupt, reduce or stop medication according to the doctor's advice.

PazopanibThe original drug has been launched in China and has entered the scope of Class B medical insurance, but reimbursement is limited to patients who meet the indications. The price of each box may be around 3,000 yuan. The price of pazopanib original drug specifications200mg*30 tablets marketed overseas may be around 1,000 RMB per box (the price may fluctuate due to exchange rates). There are also pazopanib generic drugs produced in other countries. The price of 200mg*30 tablets produced by Bangladesh pharmaceutical factory may be around 500 yuan per box (the price may fluctuate due to the exchange rate), which is cheaper. The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs.