What disease does Besponsa treat?

Olintuzumab/Olintuzumab (Besponsa) is a drug used to treat acute lymphoblastic leukemia (Acute Lymphoblastic Leukemia, ALL). ALLis a hematologic malignancy that usually originates in lymphocytes, a type of white blood cell that normally helps the body fight infection. However, ALL occurs when lymphocytes undergo malignant changes and multiply rapidly. These abnormal cells are unable to perform normal immune functions and interfere with the production of normal blood cells, including red blood cells, white blood cells, and platelets.

ALLis usually divided into two main subtypes: B cell type (B-cell ALL) and Tcell type (T-cell ALL), among which B cell typeALL is more common. Olintuzumab/Olintuzumab is mainly used to treat adult B cell type ALL , especially those who have developed resistance to traditional treatment methods or have relapsed.

Olintuzumab/OlintuzumabBelongs to a class of drugs called monoclonal antibodies. Its mechanism of action is to interfere with the growth and survival of leukemia cells by targetingCD22antigen. CD22 is a protein located on the surface of B cells. Ogaituzumab/Oinutuzumab can bind to this protein, thereby preventing leukemia cells from continuing to proliferate. This kind of treatment that targets specific molecules is called targeted therapy, and it often has lower toxicity and better therapeutic effects than traditional chemotherapy and radiation.

Ogaituzumab/Olintuzumab treatment is usually managed and supervised by a medical professional because it may cause some adverse reactions, such as fever, infection, anemia, and bleeding tendencies. TreatmentALLis often a complex process that may include a combination of drugs, a bone marrow transplant, and other supportive therapies.

Ogaintozumab/Ointozumab has been launched in China, but it is not included in medical insurance. The domestic price is around 60,000 to 70,000 yuan, which is very expensive. Patients can buy it domestically. There are only original drugs available abroad, mainly Pfizer’s original drugs, which cost more than 80,000 yuan.