What are the side effects of Palbociclib?

In clinical studies, when palbociclib (Palbociclib) was used in combination with an aromatase inhibitor (letrozole), the most common adverse reactions (≥10%) were neutropenia, infection, leukopenia, fatigue, nausea, alopecia, stomatitis, diarrhea, anemia, rash, asthenia, thrombocytopenia, vomiting, decreased appetite, dry skin, pyrexia, and dysgeusia.

In clinical studies, when palbociclib was used in combination with fulvestrant, the most common adverse reactions (≥10%) were neutropenia, leukopenia, infection, fatigue, nausea, anemia, stomatitis, diarrhea, thrombocytopenia, vomiting, alopecia, rash, decreased appetite, and pyrexia. If a patient develops new or worsening respiratory symptoms and is suspected of having pneumonia, palbociclib should be permanently discontinued. Based on findings from animal studies and its mechanism of action, palbociclib can cause fetal harm when administered to pregnant women.

The original drug of palbociclib has been launched in China and has entered the scope of Class B medical insurance, but reimbursement is limited to patients who meet the indications. The price of each box may be more than more than 4,000 yuan. The price of palbociclib's original drug, 125mg*21 tablets per box, sold overseas may be around RMB 10,000 (the price may fluctuate due to exchange rates). There are also generic palbociclib drugs produced in other countries. The price of 125mg*21 tablets produced by Bangladesh pharmaceutical factory may be around 900 yuan per box (the price may fluctuate due to the exchange rate), which is cheaper. The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs.