How much does domestically produced Palbociclib cost in 2023?

The original drug of Palbociclib (Palbociclib) has been launched in China and has entered the scope of Class B medical insurance. There are also domestically produced drugs produced by pharmaceutical companies in China, such as Qilu Pharmaceuticals, Hansoh Pharmaceuticals, etc. The drug ingredients are basically the same as those of the original drug, but the manufacturers and specifications are different, and the price is different. The price of a domestic palbociclib box may be more than 4,000 yuan.

The U.S. Food and Drug Administration (FDA) has approved palbociclib in combination with letrozole (an aromatase inhibitor) as a first-line treatment for estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) postmenopausal metastatic breast cancer. Studies have shown that palbociclib may be an inhibitor of the ABCB1 transporter and has high binding affinity to the ABCB1 transporter at the substrate binding site. This indicates that palbociclib may compete with other ABCB1 substrates for the substrate binding site of ABCB1, and its in vitro anti-cancer efficacy is significantly reduced in cancer cells overexpressing ABCB1.

The specifications of palbociclib's original drug marketed overseasThe price of 125mg*21 capsules per box may bearound RMB 10,000 (the price may fluctuate due to exchange rates). There are also generic palbociclib drugs produced in other countries. The specifications produced by Bangladesh Pharmaceutical FactoryThe price of 125mg*21 pills per box may be around 900 yuan (the price may fluctuate due to the exchange rate), which is cheaper. The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs. For more drug information and specific prices, please consult the medical consultant of Yaode.