Isatuximab (Isatuximab-irfc) Chinese instructions

1. Indications

Isatuximab-irfc is a drug used to treat multiple myeloma (Multiple Myeloma, MM). Multiple myeloma is a blood cancer caused by abnormal proliferation of plasma cells in the bone marrow. Isatuximab is often used with other medicines for the following conditions:

1.Newly diagnosed multiple myeloma patients, often as part of the initial treatment phase.

2.Treatment of relapsed or refractory multiple myeloma, especially in patients who have failed previous treatments.

2. Mechanism of action

The mechanism of action of isatuximab is based on the following key features:

1.CD38Inhibitor: Isatuximab induces cell apoptosis (cell self-destruction) and inhibits cell proliferation by binding to the CD38 molecule on the surface of multiple myeloma cells.

2.Immune activation: It can also activate natural killer cells and other cells in the immune system, enhancing their ability to attack cancer cells, thereby helping to eliminate abnormal cells.

3. Pharmacology

Isatuximab is a monoclonal antibody that interferes with the normal function of multiple myeloma cells by binding with high affinity to the CD38 molecule. It works in the following ways:

1.Inhibit cell proliferation: Binding with CD38 can lead to apoptosis of multiple myeloma cells and slow down or stop tumor growth.

2.Immunomodulation: Isatuximab can also enhance antibody-dependent cytotoxicity by activating natural killer cells and the immune system (ADCC), thereby assisting the immune system in eliminating cancer cells.

4. Dosage and usage

Isatuximab is usually given as an intravenous injection in a medical facility by a medical professional. The treatment process may take several hours, and the specific dosage and treatment regimen should be determined based on the patient's condition and the recommendations of the doctor.

The frequency and duration of medication will vary depending on the patient's condition, stage of treatment, and treatment plan, and your doctor will provide specific medication guidance.

5. Side Effects

The use of isatuximab may cause some side effects, including but not limited to:

1.Infections: Because medications may suppress the immune system, patients are more susceptible to infections.

2.Anemia and thrombocytopenia: May cause fatigue, bleeding and congestion.

3.Nausea and vomiting: Some patients may experience these digestive symptoms.

4.Fatigue: may affect the patient's quality of life.

5.Allergic reactions: including rash, urticaria, shortness of breath, etc.

6.Skin reactions: such as rash, itching or dryness.

7.Hypertension: may require monitoring and management.

Patients should monitor side effects closely during treatment and report any symptoms of discomfort to their doctor immediately.

6. Warnings and Precautions

1.Patients should follow the doctor's treatment plan and receive treatment at the specified dose and time.

2.Patients may need to undergo regular medical monitoring and examinations to evaluate the effectiveness and side effects of treatment.

3.Patients should avoid concurrent use with other immunosuppressive drugs to reduce the risk of infection.

4.Pregnant and breastfeeding women should consult their doctor before using isatuximab because it may have effects on the fetus or baby.

7. Contraindications

Isatuximab may not be suitable for some patients, especially those who are allergic to any of its ingredients. The doctor will judge whether it is suitable for use based on the patient's specific situation.

8. Drug interactions

Patients should tell their doctors about all medications they are taking, including prescription drugs, over-the-counter drugs, and supplements. Certain drugs may interact with isatuximab, affecting its effectiveness or increasing the risk of side effects.

9. Medication for Special Populations

For special populations, such as older patients, patients with impaired renal function, or patients with impaired hepatic function, dosage adjustments or other precautions may be necessary. The doctor will develop a personalized medication plan based on the patient's condition.