What lpilimumab does

Ipilimumab (Ipilimumab) works by inhibiting an important negative regulatory mechanism in the immune system, thereby enhancing the immune system's ability to attack cancer cells. It is an immune checkpoint inhibitor that mainly acts on the CTLA-4 (cytotoxicTlymphocyte antigen4) protein. The following is a detailed explanation of the role of ipilimumab:

1. Relieve immunosuppression: The main effect of Ipilimumab is to relieve the suppression of the immune system by preventing the binding of CTLA-4 and its ligands (B7-1 and B7-2). CTLA-4 is a protein expressed on T lymphocytes (part of the immune system). Its presence causes the activity of T lymphocytes to decrease, reducing the attack on cancer cells. Ipilimumab works by blocking this inhibitory effect of CTLA-4, making it easier for T lymphocytes to recognize and attack cancer cells.

2. Enhance immune response: By relieving the inhibition of CTLA-4, ipilimumab can enhance the immune system's immune response to cancer. This means that T lymphocytes in the immune system can more actively identify and attack cancer cells, increasing the aggressiveness of the immune system.

3. Long-term therapeutic effects: The therapeutic effects of ipilimumab may not be limited to the treatment period. It is sometimes described as having a long-lasting therapeutic effect, meaning that a patient's immune system continues to attack cancer cells after treatment ends. This long-term therapeutic effect makes ipilimumab an important treatment option in some cancer types.

Ipilimumab is not currently available in China, so patients cannot purchase it domestically and can only purchase it through overseas purchase channels. There are only original drugs of Ipilimumab abroad, mainly Turkish original drugs and Bristol-Myers Squibb original drugs. The price of Turkish original drugs is around 12,000 yuan, and the specifications are50mg/10ml; Bristol-Myers -Bristol-Squibb original drug price is about 11,700yuan, and the specification is also 50mg/10ml. The ingredients of the two drugs are the same.