Instructions for ibrutinib

1. Indications:

Ibrutinib (lbrutinib) is an oral drug used to treat certain types of blood cancers and lymphomas. Its main indications include:

Chronic lymphocytic leukemia (CLL): For use in adult patients, especially those who have not experienced an adequate response to at least one other prior therapy.

Small lymphocytic lymphoma (SLL): A related lymphoma that often occurs in combination with CLL.

Mucosa-associated lymphoid tissue lymphoma (MALTlymphoma): used to treat specific subtypes of B cell lymphoma.

2. Mechanism of action:

Ibrutinib is an BTK (Bruton's tyrosine kinase) inhibitor. It prevents the growth and division of abnormal B cells by inhibiting BTK activity in B lymphocytes. BTK is a key component of B cell signaling. The mechanism of action of ibrutinib is to inhibit the growth of cancer cells by interfering with this signaling, thereby reducing disease symptoms.

3. Pharmacology:

Ibrutinib is rapidly absorbed when administered orally and forms active metabolites in the body. It is mainly metabolized by the liver in the body and is tightly bound to plasma proteins. The drug has a relatively long half-life and usually needs to be taken once a day.

4. Dosage and usage:

The dosage and administration of ibrutinib are usually based on the patient's specific condition and doctor's recommendations. Generally, the recommended dose is once daily, taken by mouth, with or without food. Patients should take medications strictly as prescribed by their doctor and have regular follow-up visits to monitor the effects of treatment.

5. Side effects:

Ibrutinib may cause a range of side effects, including but not limited to:

Bleeding tendency: may cause symptoms such as easy congestion, congestion and ecchymosis.

Abnormal liver function: May result in abnormal liver function, including jaundice and hyperbilirubinemia.

Hypertension: May cause high blood pressure and requires regular monitoring and treatment.

Fatigue: May cause fatigue and feelings of weakness.

Digestive tract discomfort: Nausea, diarrhea, vomiting and other symptoms may occur.

Patients should pay close attention to any side effects and report them to their doctor promptly.

6. Warnings and Precautions:

Bleeding risk: Patients should carefully handle cuts, bruises, etc. while taking ibrutinib, and inform their doctor of any abnormal bleeding.

Liver function monitoring: Patients should undergo regular liver function tests to ensure there are no liver function abnormalities.

High blood pressure monitoring: Patients with high blood pressure need to monitor their blood pressure closely and follow their doctor's treatment recommendations.

Drug Interactions: Patients should inform their doctors of all medications they are taking because ibrutinib may interact with other medications.

7. Contraindications:

Ibrutinib may be contraindicated in the following circumstances:

Patients allergic to ibrutinib or its components.

Patients with serious heart problems such as arrhythmias.

8. Drug interactions:

Ibrutinib may interact with other drugs, so patients should inform their doctor about all medications they are taking, including prescription drugs, over-the-counter drugs, and supplements.

9. Drugs for special groups:

Special caution is required when using ibrutinib in specific populations:

Pregnant and breastfeeding women should avoid the use of ibrutinib because it may cause harm to the fetus and infant.

Dose adjustments may be required in patients with impaired hepatic function.

Dose adjustments may also be required in patients with impaired renal function.

10. Launch and price status:

Ibrutinib is currently on the market in China and is included in medical insurance. The domestic price ranges from 10,000 to 20,000. Due to different medical insurance policies in different places, the price is also different. For specific reimbursement information, please consult the local hospital pharmacy or medical insurance bureau. The cheaper types of ibrutinib abroad are generic drugs, mainly Indian generic drugs, Bangladeshi generic drugs and Laos generic drugs, with prices ranging from a few hundred to several thousand yuan. And the ingredients of generic ibrutinib drugs are basically the same as those of domestic ibrutinib drugs.

In short, ibrutinib is an important drug used to treat specific types of blood cancers and lymphomas. Its indications, mechanism of action, pharmacology, dosage and usage, side effects, warnings and precautions, contraindications, drug interactions, and use in special populations require close cooperation between patients and doctors to ensure safe and effective treatment. This leaflet provides basic information about ibrutinib, but specific dosing details should follow your doctor's recommendations and prescriptions.