What should I do if I become resistant to Obeticholic acid?

Obeticholic acid (Obeticholic acid) has been approved for the treatment of primary biliary cholangitis (PBC), an autoimmune liver disease that may lead to liver inflammation and cholestasis, ultimately causing liver damage. Obeticholic acid can reduce liver inflammation and improve liver function through interaction with receptors.

Obeticholic acid can cause liver damage, sometimes severe enough to require a liver transplant or lead to death, especially in people with cirrhosis (scarring). If you have or have had cirrhosis, tell your doctor. If a patient develops resistance to obeticholic acid, it is recommended to contact a professional doctor or hepatobiliary disease expert immediately for further evaluation and guidance. In some cases, your doctor may consider adjusting your medication dosage or giving other medications to manage your condition. Treatment of drug resistance often requires individualized treatment plans, so physician advice is crucial. In daily life, it may also be beneficial for patients to maintain a healthy lifestyle, including a reasonable diet, regular exercise, and avoiding excessive drinking.

The original drug of obeticholic acid has not yet been marketed in the country, so it has not been included in medical insurance. The original obeticholic acid drug marketed overseas is expensive, with each box costing around tens of thousands of yuan. The price is also affected by exchange rates and is unstable. It is understood that obeticholic acid has been produced as a generic drug and its ingredients are basically the same as those of the original drug. For example, the price of 5mg*30 tablets produced by a Bangladesh pharmaceutical factory is around RMB 1,000 per box (the price may fluctuate due to the exchange rate), and the price is cheap. For more drug information and specific prices, please consult a medical consultant.