Is Orlistat more effective if taken before or after meals?

Orlistat (Orlistat) may prevent your body from absorbing some fat-soluble vitamins and beta carotene. While patients are taking orlistat, they should take a daily multivitamin containing vitamins A, D, E, K, and beta-carotene. Take a multivitamin once daily, 2 hours before or 2 hours after taking Orlistat, or at bedtime.

Postprandial cholecystokinin plasma concentrations were reduced after multiple doses of orlistat in two studies, but were not significantly different from placebo in the other two experiments. No clinically significant changes were observed in gallbladder motility, bile composition, or stone formation or colonocyte proliferation rates, nor were there clinically significant reductions in gastric emptying time or gastric acidity. Furthermore, in these studies, orlistat administration had no effect on plasma triglyceride levels or systemic lipase. Use low-fat or fat-free versions of these foods and/or reduce the amount you eat. Patients should divide their daily intake of fat, carbohydrate, and protein evenly among three meals. Side effects from the drug are more likely to occur if you eat a diet high in fat or eat a meal that is very high in fat while taking orlistat.

The original drug of Orlistat has been marketed in China, but it has not yet entered the scope of medical insurance. There are also domestically produced drugs developed by other pharmaceutical companies on the market. The price of each box may be around tens of RMB, which is cheap. The price of the Indian version of Orlistat listed overseas is 120mg*84 capsules per box, which may be around a few hundred yuan (the price may fluctuate due to exchange rates). The ingredients of the two drugs are basically the same, but the manufacturers are different, and patients can choose by themselves.