Lisocabtagene maraleucel (Beryanzi) Side Effects

Lisocabtagene maraleucel(Beryanzi), as a CAR-T cell therapy, may cause a series of side effects, including but not limited to the following. Please note that the severity and incidence of these side effects vary among individuals, so each patient's experience may be different. In addition, doctors often perform detailed evaluation and monitoring of patients to manage and mitigate these side effects.

1.Cytokine Release Syndrome (CRS): CRS is a possible serious side effect that is usually caused by CAR-T cells. Symptoms may include high fever, chills, low blood pressure, increased heart rate, shortness of breath, headache, nausea, vomiting and general malaise. CRSSymptoms may appear within days of CAR-T cell injection and peak within weeks of treatment. Severe CRS may require hospitalization, including anti-inflammatory medications and other supportive care.

2.Nervous system toxicity: Some patients may experience neurological toxicity, manifesting as symptoms such as headache, ataxia, coma, delirium, and convulsions. These symptoms often develop after CAR-Tcell injection and may require special neurological monitoring and treatment.

3.Infection:CAR-Tcell therapy may cause damage to the immune system, making patients susceptible to infection. Therefore, patients need to take special care during treatment to avoid infection by bacteria, viruses, and other pathogens.

4.Blood problems: Treatment may cause blood problems such as anemia, thrombocytopenia, and leukopenia. This may increase the risk of bleeding and infection.

5.Other side effects: In addition, there are other possible side effects, including nausea, vomiting, fatigue, diarrhea, lung problems, and abnormal liver function.

It needs to be emphasized that,The risk of side effects from treatment with lisocabtagene maraleucel is very serious, so treatment must be done under professional medical supervision. Doctors will monitor and manage these side effects on a patient-by-patient basis and may need to take steps to reduce symptoms and risks. Before receiving treatment, patients and doctors should have a detailed discussion to ensure a full understanding of potential benefits and risks.