How dotalizumab (Jemperli) works

The therapeutic principle of dotalizumab (Jemperli) is based on the principle of immune checkpoint inhibition and is designed to enhance the immune system's attack on cancer cells. This drug is primarily used to treat ovarian cancers that have highly unstable microsatellite mismatches (dMMR) or lack DNA mismatch repair (dMMR). The following is a detailed explanation of the therapeutic principle of dotalizumab:

1.Immune checkpoint inhibition: Immune checkpoint is an autoregulatory mechanism used to prevent the immune system from excessive attacks on normal tissues. They are molecules, or receptors, found on the surface of immune cells, such asTcells. An important type of immune checkpoint receptor is the PD-1 (programmed death 1) receptor.

2.PD-1Interaction withPD-L1: Under normal circumstances, the PD-1 receptor and its ligandPD-L1 (Programmed death receptor ligand 1) or PD-L2 will transmit an inhibitory signal, causing T cells to stop attacking and reduce their activity. This mechanism helps maintain the balance of the immune system to prevent excessive immune responses. However, in some cases, cancer cells can use this mechanism to evade immune system attack by overexpressing PD-L1 to inhibit the activity of T cells.

3.The role of dotalizumab: Dotalizumab is an anti-PD-1 antibody drug. Its mechanism of action is to bind to the PD-1 receptor, prevent the binding of PD-1 and PD-L1, and relieve the inhibition of T cells. This means that dotalizumab can reactivate T cells so that they can attack cancer cells.

4.Enhance immune attack: The use of dotalizumab increases the ability of T cells to recognize and attack cancer cells. Cancer cells become more susceptible to recognition by the immune system, increasing the strength of the immune response. This helps overcome the mechanisms by which cancer cells escape immune surveillance.

Dotalizumab is not currently on the market in China, and it is not included in medical insurance. Patients cannot purchase it domestically and need to purchase dotalizumab through overseas channels. There are only original drugs available abroad, mainly from the United States, and the price is as high as about 50,000 yuan.