Dotalizumab (Jemperli) Chinese instructions

1. Indications

Dotalizumab (Jemperli) is an immunotherapy drug used to treat ovarian cancer with a highly unstable microsatellite mismatch (dMMR) or deficient DNA mismatch repair (dMMR). The main indications for this drug are:

Ovarian cancer with a highly unstable microsatellite mismatch (dMMR) or lacking DNA mismatch repair (dMMR).

2. Mechanism of action

The mechanism of action of dotalizumab is based on the principle of immune checkpoint inhibition. Its core functions are as follows:

Dotalizumab is an anti-PD-1 (programmed death1) antibody that works by blocking the interaction of the PD-1 receptor with < The binding of /span>PD-L1 (programmed death receptor ligand 1) relieves the inhibitory effect of T cells.

In this way, dotalizumab can reactivateT cells, enhance the immune system's attack on cancer cells, and improve the ability to recognize and eliminate cancer cells.

3. Pharmacology

The pharmacological properties of dotalizumab include:

1.Absorption: Dotalizumab is administered by injection and enters the patient's blood circulation.

2.Distribution: It can be distributed into various tissues in the body, including tumor tissue.

3.Metabolism: The metabolic pathways and drug interactions of dolutelimumab are not fully understood.

4.Excretion: Drugs and their metabolites are eliminated from the body through metabolism and excretion.

4. Dosage and usage

The dosage and usage of dotalizumab is usually determined by medical professionals based on the patient's specific conditions, including the patient's age, weight, severity of illness and other factors. In general, the usage of dotalizumab is as follows:

Dotalizumab is administered by intravenous injection and is administered by professional medical personnel in medical institutions.

Dosage and treatment frequency will be determined based on the patient's condition and follow the physician's recommendations.

5. Side Effects

Dotalizumab may cause a series of side effects, including but not limited to:

1.Immune-related skin reactions, such as rash, itching, dry skin, etc.

2.Immune-related gastrointestinal reactions, such as nausea, vomiting, diarrhea, abdominal pain, etc.

3.Immune-related liver problems may lead to abnormal liver function, jaundice, etc.

4.Immune-related lung problems, such as pneumonia, may cause difficulty breathing, coughing, etc.

5.Immune-related thyroid problems may lead to abnormal thyroid function, neck swelling, etc.

6.In addition, general side effects may occur, such as fatigue, headache, muscle and joint pain, loss of appetite, etc.

6. Warnings and Precautions

Patients and medical professionals need to be aware of the following warnings and precautions while using dotalizumab:

1.Dotalizumab may cause immune-related side effects, so patients' health needs to be monitored regularly.

2.Physicians should closely monitor patients for immune-related side effects and adjust treatment plans as needed.

3.Patients should inform their doctor about any pre-existing health problems or other medications they are taking.

7. Contraindications

Dotalizumab may not be suitable for use in certain cases and contraindications may include:

1.Patients who are allergic to dotalizumab or its components.

2.Patients with certain severe immune system diseases or autoimmune diseases.

3.Pregnant or breastfeeding women, as the safety of dotalizumab is not known to the fetus or infant.

8. Drug interactions

Drug interactions with dolutelimumab are not fully understood. Patients should inform their doctors about other medications they are taking so that their doctors can evaluate potential interactions.

9. Medication for Special Populations

The use of dotilizumab in special populations (such as elderly patients, children, etc.) may require special considerations. Medication regimens should be adjusted based on individual patient differences.

10. Listing and price situation:

Dotalizumab is not currently on the market in China, and it is not included in medical insurance. Patients cannot purchase it domestically and need to purchase dotalizumab through overseas channels. There are only original drugs available abroad, mainly from the United States, and the price is as high as about 50,000 yuan.

Detailed medication instructions and information should be obtained from your doctor or official drug instructions. Dotalizumab is an important immunotherapy drug that offers a new treatment option for patients with certain types of ovarian cancer, but it must be used under the guidance of a medical professional.