What should I do if I become resistant to ozanimod?

Ozamod (ozanimod) is a sphingosine-1-phosphate (S1P) receptor modulator that binds to S1P subtypes 1 and 5 (S1P1 and S1P5) with high affinity, leading to the internalization of S1P1 receptors in lymphocytes and preventing the mobilization of lymphocytes to inflammatory sites. It serves the purpose of treating relapsing forms of multiple sclerosis and moderate to severe active ulcerative colitis.

Ozamod may cause a transient decrease in heart rate at the beginning of dosing. OzamodThe escalating dose regimen of 0.23 mg, followed by doses of 0.46 mg and 0.92 mg, attenuated the magnitude of the decrease in heart rate. Ozamod has high oral bioavailability, has a circulating half-life of approximately 19 hours, and reaches maximum plasma concentrations after approximately 6 hours. After discontinuing Ozamod 0.92 mg, the median time for peripheral blood lymphocytes to return to the normal range is 30 days, and about 90% of patients are within the normal range within 3 months. It does not require phosphorylation for activation, and does not show cardiac abnormalities or liver toxicity. Resistance to ozanimod is a possible phenomenon that has not yet been reported.

The original drug Ozamod has been launched in China, but it has been on the market for a short time and has not been included in the medical insurance. The specific price is not yet clear, and domestic purchase channels are relatively difficult. The price of Ozamod original drug specifications0.92*28 capsules per box listed overseas may be around 19,000 yuan (the price may fluctuate due to the exchange rate), which is expensive. There is currently no generic version of Ozamod produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.