Is ozanimod a highly effective drug?

Ozamod (ozanimod) is an agonist of S1PR1 and S1PR5, and its selectivity for S1PR1 is 27 times that of S1PR5. Itis a drug used to treat multiple sclerosis (MS) and ulcerative colitis (UC) by affecting the immune system to reduce symptoms and disease progression in MS patients. Caninteraction with S1PR leads to receptor internalization and subsequent ubiquitin-proteasome-dependent degradation, preventing the receptor from re-entering the cell membrane, which results in a decrease in absolute lymphocyte count(ALC).

Based on the results of clinical trials, ozanimod has proven to be a relatively highly effective drug. The effects of Ozamod are rapidly reversible, with ALC recovering within 48-72 hours after stopping the drug, but recent studies report that ALC recovery takes longer, up to 30 days after stopping Ozamod. In a double-blind, randomized, placebo-controlled Phase I study, ozanimod demonstrated linear pharmacokinetics with dose-proportional increases and low to moderate inter-subject variability, reaching steady state within 7 days. It has a high distribution volume (5590 L), high plasma protein binding (>98%) and slow absorption (maximum concentration is reached after 6-8 hours), which results in lower systemic exposure and thus mitigates the decrease in heart rate observed after the first dose

The original drug Ozamod has been launched in China, but it has been on the market for a short time and has not been included in the medical insurance. The specific price is not yet clear, and domestic purchase channels are relatively difficult. The price of Ozamod original drug specifications0.92*28 capsules per box listed overseas may be around 19,000 yuan (the price may fluctuate due to the exchange rate), which is expensive. There is currently no generic version of Ozamod produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.