Chinese instructions for Lamivudine Dolutegravir Tablets (Dovito)

Indications:

Lamivudine dolutegravir tablets (Dovito) are mainly used to treatHIV-1 (human immunodeficiency virus-1) infection. It is an antiretroviral therapy (Antiretroviral Therapy, ART) drug indicated for use in adult patients and children over 12 years as part of the long-term treatment of HIV infection.

Mechanism of action:

1.Lamivudine (Lamivudine): Lamivudine is a nucleoside reverse transcriptase inhibitor (Nucleoside Reverse Transcriptase Inhibitor, NRTI), prevent the replication of the virus by inhibiting the reverse transcriptase of the HIV virus.

2.Dolutegravir (Dolutegravir): Dolutegravir is an integrase inhibitor (Integrase Strand Transfer Inhibitor, INSTI), which prevents the replication of the virus by preventing the HIV virus from integrating its viral DNA into the DNA of the host cell.

Pharmacology:

Lamivudine dolutegravir tablets slow down the progression ofHIV infection by inhibiting the replication ofHIV-1, reducing the viral load, enhancing the function of the immune system, and improving the patient's quality of life. Its three components work synergistically to block different stages of viral replication.

Dosage and usage:

1.Patients should use lamivudine dolutegravir tablets correctly according to the doctor’s prescription.

2.Generally, adult patients take 1 tablet orally once a day.

3.The dosage for children should be determined according to their weight and age, and should be carefully guided by a doctor.

Side effects:

The use of lamivudine dolutegravir tablets may cause some side effects, including but not limited to headache, nausea, vomiting, diarrhea, fatigue, etc. These side effects are usually mild, but if they persist or worsen, patients should tell their doctor immediately.

Warnings and Precautions:

1.Allergic reaction: If patients develop allergic reaction symptoms such as rash, urticaria, shortness of breath or swelling while taking lamivudine dolutegravir tablets, they should stop taking the medicine immediately and seek medical treatment.

2.Liver function monitoring: Patients need to have liver function monitoring during treatment to ensure that the drug does not cause inappropriate effects on the liver.

Contraindications:

This drug is contraindicated in patients who are allergic to any ingredient in lamivudine dolutegravir tablets, and in patients with a known allergy to alkaft.

Drug interactions:

Patients should tell their doctors about all medications they are taking because lamivudine dolutegravir may interact with other medications.

Medicine for special groups:

1.Pregnant and nursing women: Patients should use this medication under the supervision of a physician because it may have effects on the fetus or infant.

2.Children: Lamivudine dolutegravir tablets are suitable for children over12 years old. The dosage should be determined based on weight and age.

Listing and price status:

Lamivudine dolutegravir tablets have been launched in China and have been included in medical insurance. Patients can buy them in domestic hospital pharmacies at a price of about more than 1,000 yuan. Please consult the local hospital pharmacy for specific prices and reimbursement information. The cheaper ones abroad are mainly Indian generic drugs, which cost more than 200 yuan, and the ingredients of domestic original drugs and foreign generic drugs are basically the same.

Lamivudine Dolutegravir Tablets (Dovito) is a combination antiretroviral drug used to treatHIV-1 infection. Patients should use their medications correctly and according to their doctor's prescriptions and recommendations, and pay close attention to side effects and warning signs. Regular monitoring and follow-up by a doctor are required during treatment to ensure the safety and effectiveness of the treatment. The information provided in this article is for reference only and patients should follow the official drug package insert and physician's guidance.