What should I do after taking a shower after taking Ofatumumab?

After taking ofatumumab (Ofatumumab), it is recommended that patients wait for a while before taking a bath. Ofatumumab may weaken the immune system and increase the risk of infection. Therefore, make sure the bathroom environment is clean and hygienic before taking a bath, and try to reduce contact with others, especially people with infectious diseases. After bathing, closely monitor your body's reactions. If you experience any unusual symptoms or discomfort, inform your doctor promptly.

Ofatumumab, originally approved to treat chronic lymphocytic leukemia and multiple sclerosis, is a monoclonal antibody drug that reduces the number of B cells and the antibodies produced by these cells. It modulates the immune system by targeting and inhibiting the activity of B lymphocytes. Although the exact mechanism of action of ofatumumab is unclear, it is understood that the FAB portion of ofatumumab selectively binds and inhibits CD20, a transmembrane phosphoprotein expressed on B lymphocytes. The region where ofatumumab binds to CD20 is different from that of other anti-CD20 antibodies. This leads to B cell (and T cell) depletion through complement-mediated CD20+ B cell lysis and antibody-dependent cell-mediated cytotoxicity.

The original drug of ofatumumab has been launched in China and has also been included in medical insurance. Only patients who meet the indications can be reimbursed. The price is around tens of thousands of yuan, and domestic purchase channels are relatively difficult. The European version of ofatumumab original drug specifications20mg/0.4mL each sold overseas may cost around RMB 16,000 (the price may fluctuate due to the exchange rate). It is expensive and there are currently no generics of ofatumumab. For more drug information and specific prices, please consult a medical consultant.