Bedaquiline used with Delamanid

Studies have shown that the new anti-tuberculosis drugs Delamanid and bedaquiline, used alone or sequentially in the treatment of patients with multidrug-resistant tuberculosis, show good efficacy and safety in combination with the background regimen recommended by WHO. Previous clinical trials have shown that after 24 weeks of treatment with bedaquiline, 79-81% of patients had sputum cultures that became negative at week 24, and 62-72% of patients had sputum cultures that became negative at week 120. In addition, the optimized background regimen combined with delamanid for 6-8 months resulted in a sputum culture conversion rate of 65% at 8 weeks and a good outcome rate of 75% after 24 months.

In a recent large observational cohort study in a different setting, in addition to experimental conditions, bedaquiline-containing regimens achieved a sputum culture conversion rate of over 90% at the end of treatment, even with high rates of fluoroquinolone-resistant tuberculosis (64.5%) and extensively drug-resistant tuberculosis (45.6%). High culture conversion rates have also been reported in other recent cohort studies of new antituberculosis drugs in MDR-TB patients. In this study, the overall culture conversion rate was 71%, although 69% of patients had fluoroquinolone-resistant MDR-TB and 26% had XDR-TB. This is relatively high compared with percentages in previous clinical trials but not as high as in observational cohort studies. This discrepancy may be due to differences in patient status, clinical settings, and treatment regimens.

The original drug Delamani has been launched in China and is included in the scope of Class B medical insurance. Reimbursement is limited to patients with multi-drug-resistant tuberculosis. Specifications The price of each box of 50mg*60 tablets may be around RMB 6,000. The price of the Russian version of the original drug Dramani, 50mg*48 tablets, sold overseas may be around RMB 1,000-2,000 per box (the price may fluctuate due to the exchange rate). There is currently no generic version of Dramani available on the market. For more drug information and specific prices, please consult Yaode’s medical consultant.