Chinese instructions for lapatinib

Indications: Lapatinib is mainly used to treatHER2-positive breast cancer, especially in patients who have received other treatments but failed to respond. It can be used as a monotherapy or in combination with other medications.

Mechanism of action: Lapatinib is a targeted therapy drug that reduces the growth and division of breast cancer cells by inhibiting the activation of HER2 and EGFR receptors. These two receptors play key roles in breast cancer, with overactive HER2 and EGFR promoting tumor development.

Pharmacology: Lapatinib reduces the proliferation and viability of cancer cells by binding to HER2 and EGFR receptors and blocking their signaling pathways.

Dosage and usage: The usage and dosage of lapatinib should be according to the doctor's prescription. Generally, patients take oral lapatinib tablets at the dose prescribed by their doctor daily, usually after a meal. The medication plan will be determined according to the patient's specific situation and needs to follow the doctor's recommendations.

Side effects: Lapatinib may be associated with some side effects, including but not limited to: diarrhea, skin rash, nausea and vomiting, fatigue, headache, abnormal liver function, heart problems, digestive tract problems, etc.

Warnings and Precautions:

1.You should receive a comprehensive medical evaluation before using lapatinib.

2.Liver function and heart function must be monitored regularly.

3.Patients should pay close attention to side effects and report them to their doctor in a timely manner.

4.Pregnant and breastfeeding women should avoid using lapatinib.

Contraindications:

Lapatinib is generally not suitable for patients with the following conditions:

1.Patients who are allergic to lapatinib or any ingredient in the drug.

2.Pregnant and lactating women.

3.Patients with severe heart problems.

Drug Interactions: While taking lapatinib, patients should inform their doctor about all medications they are taking, including prescription drugs, over-the-counter drugs, and supplements, as some drugs may interact with lapatinib.

Medication for special populations: For elderly patients, patients with impaired liver function, and patients with impaired renal function, dose adjustment or special attention may be required according to the situation.

Availability and price: Lapatinib has been launched in China, but it has not yet been included in medical insurance. Patients can purchase it domestically at a price of around 5,000 to 6,000 yuan. Please consult the local hospital pharmacy for specific prices. There are original lapatinib drugs and generic drugs abroad. The original drug is cheaper than the original drug in Türkiye, which costs more than 2,000 yuan. Generic drugs include Indian generic drugs and Bangladeshi generic drugs, and the price is around a few hundred yuan. The ingredients of domestic original drugs, foreign original drugs and generic drugs are basically the same.