What are the effects of Olaparib?

As a first-in-classPARPi, olaparib has undergone comprehensive clinical evaluation as monotherapy and combination therapy in various malignancies. Lynparza has shown stable efficacy in diseases such as ovarian cancer, breast cancer and gastric cancer, and its efficacy seems to be more obvious in patients with BRCA mutated tumors. Previous meta-analyses have shown that the use of olaparib improves progression-free survival (PFS) but did not show significant efficacy in overall survival (OS).

Only three phase II controlled trials (RCTs) evaluating the efficacy of olaparib in ovarian cancer were analyzed in this meta-analysis, including 1957 patients from 8 RCTs, demonstrating that olaparib treatment provides substantial benefits in terms of PFS, OS and overall response rate (ORR). Furthermore, with the exception of anemia and decreased appetite, similar risks of serious hematological and non-hematological toxicities were found between olaparib-containing and non-olaparib-containing treatments.

Lynparza The original drug has been launched in China and has entered the scope of Class B medical insurance, but it is only available to patients who meet the indications. The price of each box of 150mg*56 tablets may be around RMB 6,000. There are price differences for drugs of different specifications. There are also Olaparibgeneric drugs produced overseas. The specifications produced by Bangladesh pharmaceutical factories150mg*120 tablets per box may cost around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the Olaparib original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.