Can Olaparib really cure cancer in two years?

Olaparib may not cure cancer in two years. Two-year first-line maintenance treatment with olaparib continues to provide sustained responses to women with newly diagnosed BRCA-mutated advanced ovarian cancer who achieved complete or partial responses to first-line platinum-based chemotherapy, according to five-year follow-up data from the Phase 3 SOLO-1 trial. Fewer than half of patients with newly diagnosed late-stage ovarian cancer survive 5 u200bu200byears, and the risk of recurrence remains high. Despite improvements in treatments, recurrent ovarian cancer is incurable in most patients.

The SOLO-1 trial is the first to report the efficacy of a PARP maintenance inhibitor in newly diagnosed advanced ovarian cancer. Most women diagnosed with ovarian cancer go on to be diagnosed at an advanced stage. The latest analysis after 5 years of follow-up showed that the benefits of maintaining olaparib persisted after the end of treatment, with a hazard ratio for median survival (PFS) of 0.33, which was significant, indicating that women in the olaparib group had a 67% reduction in disease progression or death. After randomization, almost half of the patients in the olaparib group remained progression-free for 5 years. PFS in the olaparibgroup was 56 months, compared with 13.8 months in the placebo group, so an additional 3.5 years. The number of patients who were progression-free after 5 years more than doubled with olaparib compared with placebo, at 20.5% versus 48.3%.

Lynparza The original drug has been launched in China and has entered the scope of Class B medical insurance, but it is only available to patients who meet the indications. The price of each box of 150mg*56 tablets may be around RMB 6,000. There are price differences for drugs of different specifications. There are also Olaparibgeneric drugs produced overseas. The specifications produced by Bangladesh pharmaceutical factories150mg*120 tablets per box may cost around RMB 4,000 (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the Olaparib original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.