How many years can you live taking Nilotinib?

Nilotinib (Nilotinib) is a second-generation tyrosine kinase inhibitor. Based on the results of a prospective randomized study of nilotinib and imatinib, it has been approved for the first-line treatment of chronic myelogenous leukemia in the chronic phase. There is currently very little data on first-line nilotinib treatment. The first long-term, 6-year results from the investigator-initiated GIMEMA multicenter phase 2 single-arm trial of nilotinib 400 mg twice daily as first-line treatment in 73 patients with chronic phase chronic myelogenous leukemia.

The six-year overall survival and progression-free survival rates were 96%, and one patient died after progression to blast crisis. Six years later, 75% of patients were still taking nilotinib. The cumulative incidence of major molecular response was 98%; only one patient was confirmed to have lost a major molecular response. The cumulative incidence of profound molecular reaction (MR 4.0) was 76%. Thirty-four percent of these patients had a stable deep molecular response (≥2 years). After 24-76 months of treatment, 15% of patients experienced cardiovascular adverse events, mainly due to arterial thrombosis. They are more common in older patients and in patients with baseline cardiovascular risk factors. None are fatal, although there is associated morbidity.

The original drug Nilotinib is marketed in China under the name Nilotinib and is covered by medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of 150mg*120 tablets per box may be around 9,000 yuan. The Indian version of Nilotinib is available overseas. The price of Nilotinib's original drug, 150mg*28 capsules per box, may be around RMB 1,000 (the price may fluctuate due to exchange rates). The ingredients of the original drug sold domestically and abroad are basically the same. Currently, there is no generic version of Nilotinib produced and launched. For more drug information and specific prices, please consult Yaode Medical Consultants.