How about the Indian version of Nilotinib?

Nilotinib marketed overseas (Nilotinib) is an original drug developed in India, with the trade name Tasigna. There are currently no generic drugs produced by other manufacturers in India. Nilotinib, an oral inhibitor of Abelson protein tyrosine kinase activity, is approved for the treatment of patients with newly diagnosed chronic myelogenous leukemia (CML) in the chronic phase and in patients with chronic or accelerated phase CML who may be resistant or intolerant to prior therapy.

Nilotinib is rapidly absorbed, with peak serum concentrations reaching peak serum concentrations approximately3 hours after administration. Area under the 24-hour plasma drug concentration-time curve and peak serum concentration of nilotinib at dose-proportional doses of 50 to 400 mg once daily. According to in vitro studies, nilotinib is metabolized primarily by hepatic cytochrome P450 (CYP) 3A4. In the clinical setting, nilotinib exposure is significantly reduced by rifampicin induction of CYP3A4 and significantly increased by ketoconazole inhibition of CYP3A. The bioavailability of nilotinib was increased by 82% when taken with a high-fat meal compared to the fasted state. The incidence of elevated total bilirubin at all levels was positively correlated with steady-state nilotinib trough concentrations.

Nilotinib marketed overseas Nilotinib's original drug is marketed domestically as nilotinib and is covered by medical insurance, but reimbursement is limited to patients who meet the indications. Specifications The price of 150mg*120 capsules per box may be around 9,000 yuan and is sold overseas. The price of the Indian version of the original drug, 150mg*28 capsules per box, may be around RMB 1,000 (the price may fluctuate due to exchange rate effects). The ingredients of the original drug sold domestically and abroad are basically the same. Currently, there is no generic version of Nilotinib produced and launched. For more drug information and specific prices, please consult Yaode Medical Consultants.