What are the adverse reactions of using Lorlatinib?

Lolatinib (Lorlatinib), as a targeted therapy, can cause adverse reactions in some patients. The severity and specific manifestations of these adverse reactions vary among individuals. The following are some common adverse reactions that may be associated with lorlatinib treatment:

1.Fatigue (Fatigue): Fatigue is one of the most common adverse reactions when using lorlatinib. Patients may experience extreme fatigue and weakness, which may interfere with daily life and activities. Moderate rest and reasonable activity can help relieve fatigue.

2.Shortness of Breath: Some patients may experience shortness of breath while taking lorlatinib. This may require professional medical evaluation, as severe shortness of breath may be a sign of lung problems.

3.Cough (Cough): Cough is a common side effect and is usually mild. If the cough becomes severe or is accompanied by other uncomfortable symptoms, such as sputum production or shortness of breath, patients should consult a doctor promptly.

4.Nausea and Vomiting: Lorlatinib may cause mild nausea and vomiting. These symptoms can usually be relieved by taking medication after meals or using anti-nausea medications. If nausea and vomiting persist or worsen, patients should consult their doctor.

5.Headache: Some patients may experience headache while taking lorlatinib. This is usually mild and can be relieved with rest and over-the-counter medications.

6.Constipation (Constipation) and diarrhea (Diarrhea): Lorlatinib can also cause intestinal problems, including constipation and diarrhea. Patients can manage these problems with diet and medication, but if they persist, they should consult a doctor.

7.Hypertension (Hypertension): Lorlatinib may cause high blood pressure. During treatment, the patient's blood pressure should be monitored frequently, and medications should be taken to control high blood pressure if necessary.

8.Visual Disturbances (Visual Disturbances): Some patients report visual disturbances, such as blurred vision, halos, flickers, etc. while using lorlatinib. These symptoms are usually temporary, but patients should tell their doctor immediately to rule out the risk of vision problems.

9.Elevated Liver Enzymes: Lorlatinib may cause abnormal liver function, manifested by elevated liver enzymes. Doctors usually monitor this condition by regularly checking a patient's liver function.

It should be emphasized that different patients may show different sensitivities and severity of adverse reactions to lorlatinib. Patients should be closely monitored for adverse reactions while taking lorlatinib and an appropriate management plan should be developed with their physician. Don’t hesitate to consult a medical professional to ensure optimal treatment results and comfort.

Lorlatinib has been launched in China and is included in medical insurance. Patients can purchase it domestically, but the price is relatively high, about 10,000 to 20,000 yuan. For details, please consult the local hospital pharmacy. There are original drugs and cheaper generic drugs abroad. The cheaper ones are the original drugs from Turkey, which cost more than 1,000 yuan, and the original drugs from Hong Kong, China, which cost about 30,000 yuan. Generic drugs are mainly generic drugs from Laos and Bangladesh. The price is about several thousand yuan, and the ingredients of the original drugs and generic drugs are basically the same.