What are the side effects of Nirmatrelvir/Ritonavir combination?

Nirmatrelvir/Ritonavir tablet combination Paxlovid (Nirmatrelvir/Ritonavir) is an oral antiviral drug used to treat mild to moderate novel coronavirus infection. It is used in people 12 years and older who weigh at least 88 pounds (40 kilograms) and are at high risk for serious illness, including hospitalization or death. Most people tolerate the nematvir/ritonavir combination tablets well.

In clinical trials, adverse reactions of the nematvir/ritonavir tablet combination include dysgeusia, diarrhea, hypertension and myalgia. Other side effects may include hypersensitivity reactions, hepatotoxicity and the development of HIV drug resistance in patients with uncontrolled or undiagnosed HIV infection. Anaphylaxis (hypersensitivity) may manifest as rash, urticaria, difficulty swallowing, difficulty breathing, angioedema, and/or anaphylaxis. Hepatotoxicity may manifest as elevated transaminases and clinical hepatitis, including symptoms such as loss of appetite, jaundice (yellowing of the skin and whites of the eyes), dark urine, light-colored stools, itchy skin, and abdominal pain.

NematrevirThe combination of nematvir/ritonavir tablets has been launched in China. Due to its short time on the market, it has not been included in the medical insurance. The domestic price has not yet been determined. The original drug of nematvir/ritonavir tablet combination marketed overseas, the specification is nematvir 150mg + ritonavir 100mg)*30 tablets per box, the price may be around 2,000 yuan (the price may fluctuate due to the exchange rate), India The price of each box of the generic Nematvir/Ritonavir tablet combination produced by the pharmaceutical factory may be around RMB 1,000 (the price may fluctuate due to the exchange rate). The ingredients of the two drugs are basically the same. For more drug information and specific prices, please consult Yaode Medical Consultant.