What are the side effects of Nintedanib?

Nintedanib has been approved by the U.S. Food and Drug Administration (FDA) to treat certain types of interstitial lung disease (ILD), which include shortness of breath, dry cough, feeling tired and chest discomfort. It is used for types of ILD that cause scarring of the lungs, such as idiopathic pulmonary fibrosis (IPF), certain chronic fibrosing interstitial lung diseases (ILDs), and Nintedanib helps lung function in people with systemic sclerosis-related interstitial lung disease.

In clinical studies of nintedanib, common side effects include anorexia, nausea, vomiting, diarrhea, abdominal pain, gastrointestinal perforation, weight loss, arterial thromboembolism (including myocardial infarction), bleeding, hypothyroidism, elevated liver enzymes, and headache. Adverse reactions such as drug-induced liver injury, non-serious and severe bleeding events, proteinuria, pancreatitis, thrombocytopenia, rash, and pruritus have been discovered after nintedanib was marketed.

The original drug of nintedanib is marketed in China as nintedanib ethanesulfonate soft capsules and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 150mg*30 capsules may be more than 4,000 yuan. Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 capsules produced by BDR Pharmaceutical Factory in India may be several hundred yuan per box (the price may fluctuate due to exchange rates). Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad.