Nintedanib resistance management

The PK properties of Nintedanib are similar in healthy volunteers, patients with idiopathic pulmonary fibrosis (IPF), patients with chronic fibrosis-progressive interstitial cystitis, patients with systemic sclerosis-related interstitial lung disease, and cancer patients. As the dose increases (dose range is 50-450 mg once daily; 150-300 mg twice daily).

The cumulative AUC in patients with IPF after multiple doses was 1.76 times, and steady-state plasma concentrations were reached within one week of administration. Nintedanib trough concentrations remained stable for over a year. Drug resistance usually refers to the situation where the effect of the drug gradually weakens or becomes ineffective after the patient uses the drug for a long time. Patients first need to make sure they are using nintedanib correctly and as recommended by their doctor, and that they follow the prescribed dosage and frequency. Poor medication compliance may lead to the development of drug resistance. When resistance develops, doctors may consider increasing the dose of nintedanib to help increase the drug's effectiveness. Dosage adjustments should be made under the guidance of a physician. If drug resistance persists or cannot be effectively controlled, doctors may need to look for other treatment alternatives that are ineffective with nintedanib. However, everyone's body is different and their resistance to drugs is different. If you feel unwell, please inform your doctor in time.

The original drug of nintedanib is marketed in China as nintedanib ethanesulfonate soft capsules and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 150mg*30 capsules may be more than 4,000 yuan. Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 capsules produced by BDR Pharmaceutical Factory in India may be several hundred yuan per box (the price may fluctuate due to exchange rates). Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad.