Why doctors don’t recommend taking nintedanib

Taking idiopathic pulmonary fibrosis (IPF) as an example, inIPF patients, nintedanib (Nintedanib)Treatment was not associated with serious adverse events but was associated with an increase in gastrointestinal events, particularly diarrhea (62.4% in the treatment group and 18.4% in the placebo group). These events were mild to moderate, resulting in a low discontinuation rate of 4.4% in clinical trials. Additionally, diarrhea tends to improve after the first month of treatment.

In theINPULSIS trial, 44% of diarrhea cases occurred within the first month of treatment, and 67% occurred within the first three months. However, gastrointestinal adverse events can be controlled by reducing the nintedanib dose to 100 mg twice daily or temporarily discontinuing nintedanib as needed. To control diarrhea, concomitant use of loperamide and appropriate nutrition is recommended without negatively affecting antifibrotic efficacy. Before patients are treated with nintedanib, doctors will determine the use of the drug based on the severity of the condition. Patients are not allowed to adjust the drug dosage and medication by themselves.

The original drug of nintedanib is marketed in China as nintedanib ethanesulfonate soft capsules and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 150mg*30 capsules may be more than 4,000 yuan. Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 capsules produced by BDR Pharmaceutical Factory in India may be several hundred yuan per box (the price may fluctuate due to exchange rates). Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad.