What should I do if I become resistant to Nintedanib?

Nintedanib(Nintedanib) inhibits a variety of receptor and non-receptor tyrosine kinases, which are signaling proteins that function as on/off switches in many cell-to-cell communications. Tyrosine kinases play important roles in cell growth, differentiation, and metabolism, and there is substantial evidence that platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), and fibroblast growth factor receptor (FGFR), as well as non-receptor tyrosine kinases, are associated with the progression of scar tissue and pulmonary fibrosis and other interstitial lung diseases.

The terminal elimination half-life of nintedanib is approximately 10-15 hours, and accumulation after repeated twice-daily dosing is negligible. Nintedanib was safe and well tolerated when used in daily practice, with discontinuation rates higher than those reported in clinical trials (44.8% at 12 months versus 25% in the infusion group). Most adverse events were gastrointestinal, with cardiovascular-related events and liver dysfunction reported less frequently. The discontinuation rate due to diarrhea was 7.2%. Patients can restore the previous efficacy of nintedanib by adjusting the drug dosage, but this must be done under the guidance of a doctor.

The original drug of nintedanib is marketed in China as nintedanib ethanesulfonate soft capsules and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 150mg*30 capsules may be more than 4,000 yuan. Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 capsules produced by BDR Pharmaceutical Factory in India may be several hundred yuan per box (the price may fluctuate due to exchange rates). Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad.