Is it effective to take 1 tablet of Nintedanib a day?

The anti-fibrotic drug Nintedanib is often used to treat idiopathic pulmonary fibrosis (IPF), a special form of chronic progressive fibrotic pneumonia whose cause is unknown. Nintedanib is a triple kinase inhibitor of platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR) and Src family kinases, and has been approved for the treatment of IPF.

Studies have shown that nintedanib inhibits the proliferation and activation of human fibroblasts and exhibits anti-fibrotic and anti-inflammatory activities. Nintedanib comes as an oral capsule that is usually taken twice daily. It comes in two strengths (150 mg and 100 mg). The target dose is 150 mg twice daily. The dose may be reduced in patients who experience side effects or cannot tolerate the drug. About six months of treatment with nintedanib is needed before improvements in lung volume are seen. Nintedanib should be taken 1 pill a day under the guidance of a doctor.

The original drug of nintedanib is marketed in China as nintedanib ethanesulfonate soft capsules and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 150mg*30 capsules may be more than 4,000 yuan. Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 capsules produced by BDR Pharmaceutical Factory in India may be several hundred yuan per box (the price may fluctuate due to exchange rates). Its pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad.