Is there a difference between domestic and imported Nintedanib?

Nintedanib （Nintedanib） The original drug is marketed in China as nintedanib ethanesulfonate soft capsules, and has entered the scope of Class B medical insurance. Currently, there is also a domestically produced drug nintedanib produced and marketed in China. Its pharmaceutical ingredients are basically the same as those of the original drug. The production specifications may be different, and the price is relatively cheap. Nintedanib original drug specifications150mg*30 pills per box may cost more than 4,000 yuan,nintedanib domestic drug specifications150mg*30 pills per box may cost more than 1,000 yuan.

Nintedanib is a novel oral selective TKI targeting VEGF, FGF and all isoforms of PDGFR alpha and beta, as well as RET and FLT3. Nintedanibis generally well tolerated and has a favorable cardiovascular safety profile in a variety of oncological diseasesincludingpulmonary fibrosis and systemic sclerosis-related interstitial lung disease. In a randomized phase III trial, the most common adverse event was also gastrointestinal; specifically, the incidence of diarrhea G2 was almost 22% in the nintedanib group compared with 2% in the placebo group. Drug-related adverse events leading to death occurred in 3 patients in the nintedanib group, but none of these adverse events were related to cardiovascular events (diarrhea, renal failure, and peritonitis).

Nintedanib Original drug available overseas has Turkish version and Indian version, specificationsThe price of 150mg*60 capsules per box may be more than 5,000 RMB (the price may fluctuate due to the exchange rate). There are also nintedanib generic drugs produced overseas in other countries. For example, the price of 150mg*30 pills per box produced by BDR Pharmaceutical Factory in India may be several hundred yuan (the price may fluctuate due to the exchange rate). Its drug ingredients are basically the same as those of the original drugs sold domestically and abroad. When purchasing overseas drugs, consult a medical consultant.