How much does a box of Neratinib cost?

Neratinib (Neratinib) is an oral, second-generation pan-HER TKI that irreversibly binds to cysteine residues Cys773 and Cys805 in the ATP pocket of the epidermal growth factor receptor (EGFR), HER2 and HER4 tyrosine kinase domains.

Based on the results of the ExteNET and NALA trials, the U.S. Food and Drug Administration (FDA) has approved neratinib for patients with adjuvant and metastatic HER2-positive (overexpression/amplification) breast cancer. Additionally, neratinib demonstrated significant antitumor activity in preclinical models of HER2-negative/non-amplified breast cancer and other HER2-mutant solid tumors. In ER-positive HER2 mutant cell lines, ER signaling is inhibited and cells are resistant to endocrine therapy via estrogen deprivation or fulvestrant treatment; sensitivity is restored after exposure to neratinib. Dual inhibition with neratinib and fulvestrant is required to inhibit the growth ofER-positive HER2 mutation model, which means that both ER and HER2 signaling pathways need to be inhibited.

NeratinibThe original drug is marketed in China as neratinib maleate tablets and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 40mg*180 tablets may be around 7,000 yuan. Generic drugs of neratinib are also sold overseas. The drug ingredients are basically the same as those of the original drug. The price of 40mg*180 tablets produced by Bangladesh pharmaceutical factory may be around 4,000 yuan per box (the price may fluctuate due to the exchange rate). For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.