Best time to take Neratinib

Neratinib (Neratinib) and its main active metabolite M3. The Tmax of M6 and M7 is 2-8 hours. Taking it with a high-fat meal increases Cmax by 1.7-fold and total exposure by 2.2-fold. Taking it with a standard meal increases Cmax by 1.2-fold and total exposure by 1.1-fold. Taking gastric acid reducing agents (such as proton pump inhibitors) can reduce Cmax by 71% and total exposure by 65%.

The recommended dose of neratinib is 240 mg (six 40 mg tablets) taken orally once daily with food for 12 months. Patients should take neratinib whole tablets at the same time each day (do not split, chew, or crush). If a patient forgets a dose, the patient should be advised to skip the dose and continue taking neratinib at the same scheduled time the next day. Patients with severe hepatic impairment (Child–Pugh class C) require a reduction in the starting dose of neratinib to 80 mg once daily. If necessary, dose interruptions and reductions can be made to ensure patient safety and resistance to neratinib.

NeratinibThe original drug is marketed in China as neratinib maleate tablets and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 40mg*180 tablets may be around 7,000 yuan. Generic drugs of neratinib are also sold overseas. The drug ingredients are basically the same as those of the original drug. The price of 40mg*180 tablets produced by Bangladesh pharmaceutical factory may be around 4,000 yuan per box (the price may fluctuate due to the exchange rate). For more information about overseas drugs and specific prices, please consult Yaode Medical Consultant.