Neratinib maleate (Neratinib) buy in India

Neratinib (Neratinib) is a pan-African, irreversible TKI with potent preclinical activity in trastuzumab-resistant breast cancer models. Approved for marketingFor long-term adjuvant treatment of adult patients with early-stage HER2 overexpression/amplification of breast cancer after trastuzumab-based adjuvant therapy. Neratinib is the first extended adjuvant therapy, a form of treatment taken after initial treatment to further reduce the risk of the cancer coming back. Neratinib is indicated for adult patients who have previously received a regimen that included trastuzumab.

Neratinib is a4-anilino-3-cyanoquinoline derivative formulated as neratinib maleate in tablets. Neratinib is available in the form of oral tablets after approval. Each tablet contains 40 mg of neratinib, which is equivalent to 48.31 mg of neratinib maleate. Neratinib is absorbed relatively slowly, with an average tmax of 3-6.5 hours. The steady-state Cmax and area under the curve (AUC) of neratinib increased non-linearly with increasing dose, reaching a plateau between doses of 320-400 mg. After repeated daily administration of 240 mg of neratinib, the average accumulation ratio was 1.14, indicating that the drug did not accumulate significantly. After 240 mg of neratinib was taken with food, the average elimination half-life was 14 hours.

NeratinibThe original drug is marketed in China as neratinib maleate tablets and is covered by Class B medical insurance, but reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 40mg*180 tablets may be around 7,000 yuan. Generic drugs of Neratinib are also sold overseas. The ingredients are basically the same as those of the original drug. The price of 40mg*180 tablets produced by Bangladesh pharmaceutical factory may be around RMB 4,000 per box (the price may fluctuate due to the exchange rate). There are currently no generic drugs produced by Indian pharmaceutical factories. There may be original drugs sold locally in India. For more information about overseas drugs and specific prices, please consult the medical consultant of Yaode.