How many years should you take Niraparib at most?

Current guidelines recommend niraparib as a treatment option for patients with advanced epithelial high-grade ovarian cancer who respond to platinum-based chemotherapy. Niraparib is recommended as a treatment option for patients who have not previously received bevacizumab, regardless of BRCA1 or 2 mutation status. In patients previously treated with bevacizumab, niraparib is the recommended option for patients with BRCA1 or 2 mutations, but not for patients with wild-type or unknown BRCA1 or 2 mutation status.

For all patients, the recommended duration of niraparib therapy is36 months or until disease progression or unacceptable toxicity. The American Society of Clinical Oncology recommends niraparib as a treatment option for all women who have achieved a partial or complete response to platinum-based chemotherapy for stage III or IV high-grade serous or endometrioid ovarian cancer. The recommended treatment duration is 3 years, which may be extended if the patient continues to achieve clinical benefit. Although maximum treatment duration and recommended patient FIGO stage are specified in clinical guidelines, niraparib's prescribing information does not specify a maximum treatment duration, and the approved indications are not restricted by FIGO stage.

NiraparibThe original drug has been launched in China and is included in medical insurance, but reimbursement is limited to eligible patients. The price of a common specification100mg*30 capsules per box may be more than 5,000 yuan. The original niraparib drug marketed overseas is more expensive than domestically. There are also generic niraparib drugs produced in other countries. Their pharmaceutical ingredients are basically the same as those of the original niraparib drug sold domestically and abroad. The price of 100mg*30 tablets per box produced by a Bangladesh pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to exchange rates).