Effects of taking Niraparib for one month on ovarian cancer

The PARP inhibitor Niraparib (Niraparib) is promising for the treatment of recurrent ovarian cancer. The PARP inhibitor niraparib may be an effective treatment option for some women with ovarian cancer, according to findings from a large phase III clinical trial. Results from a trial showed that treatment with niraparib significantly improved the time to progression-free survival in patients with platinum-sensitive ovarian cancer who had relapsed after prior treatment. Progression-free survival improved regardless of whether the patient's tumor had changes that impair DNA repair, such as mutations in the BRCA1 or BRCA2 genes.

Ovarian cancer is the most lethal gynecological malignant tumor, of which 70% are diagnosed at an advanced stage. Although most ovarian cancer patients are sensitive to standard first-line treatments including cytoreduction and platinum-based chemotherapy, approximately 80% of patients relapse within 1-2 years after initial treatment and gradually develop platinum-resistant ovarian cancer, accompanied by a significantly shortened survival. All adverse reactions occurred within 1 month of niraparib treatment, with most occurring within 1 week. The most common AEs leading to dose reduction and treatment interruption were severe thrombocytopenia and vomiting, but nighttime dosing may help relieve gastrointestinal symptoms.

NiraparibThe original drug has been launched in China and is included in medical insurance, but reimbursement is limited to eligible patients. The price of a common specification100mg*30 capsules per box may be more than 5,000 yuan. The original niraparib drug marketed overseas is more expensive than domestically. There are also generic niraparib drugs produced in other countries. Their pharmaceutical ingredients are basically the same as those of the original niraparib drug sold domestically and abroad. The price of 100mg*30 tablets per box produced by a Bangladesh pharmaceutical factory may be more than 1,000 yuan (the price may fluctuate due to exchange rates).