Melphalan/Melphalan’s mechanism of action

Melphalan/Melphalan (Melphalan) is a chemotherapy drug commonly used to treat multiple myeloma (Multiple Myeloma) and other leukemias, lymphomas and solid tumors. Its mechanism of action involves interference and killing of cancer cells, mainly including the following aspects:

1.Cross-linkingDNA:Melphalan/Melphalan is an alkalinizing agent (Alkylating Agent), which can combine with the nitrogen bases in DNA to form DNA appendages. These appendages will interfere with the stability of the DNA double helix structure and prevent the normal division and replication of the DNA chain. This results in DNA damage, and cancer cells cannot effectively carry out DNA repair, leading to cell death.

2.Prevent cell division:Melphalan/Melphalan can also affect the division of cancer cells. It interferes with the polymerization of microtubules, components of the cytoskeleton necessary for cell division. This makes it difficult for cancer cells to complete normal mitosis, further leading to cell death or arrest.

3.Immunosuppression: Melphalan/Melphalan also has immunosuppressive effects, inhibiting the activity of the immune system and reducing the attack on cancer cells. This can be useful during treatments such as bone marrow transplants, as it can reduce the risk of the immune system attacking the graft after transplantation.

It should be noted that Melphalan/MelphalanIt not only affects cancer cells, but also has certain toxic effects on normal cells. Therefore, the patient's blood parameters and physical condition need to be carefully monitored when using it to ensure that the effect of the treatment is maximized while minimizing toxic side effects. In addition, Melphalan/Melphalan is often used with other medications to increase the effectiveness of the treatment. Treatment options will vary based on the patient's specific situation.

Melphalan/Melphalan’s oral medicines and injections have been launched in China. The oral medicines have been included in the medical insurance, but the injections have not yet been included in the medical insurance. For specific prices and reimbursement, please consult the local hospital pharmacy and the local medical insurance bureau. Foreign original drugs include European original drugs and Turkish original drugs. European original drugs cost about more than a thousand yuan, and Turkish original drugs cost about a few hundred yuan. In addition, there are Indian generic drugs, the price of which is also around a few hundred yuan. The ingredients of original drugs and generic drugs are basically the same.