Chinese instructions for Mitotane

1. Indications:

Mitotan is mainly used to treat the following two diseases:

1.Pheochromocytoma (pheochromocytoma): A rare tumor originating from the adrenal gland. Its malignant variant can cause excessive secretion of catecholamine hormones, causing high blood pressure, heart palpitations and other symptoms.

2.Testicular medullary cell tumor (adrenocortical carcinoma): This is a type of adrenocortical cancer. Mitotane can be used to inhibit the growth of the tumor.

2. Mechanism of action and pharmacology:

The main mechanism of action of mitotane is to reduce the synthesis of catecholamines by destroying adrenocortical cells. This helps control excessive secretion of hormones in patients with pheochromocytoma, as well as inhibiting the growth of testicular medullary cell tumors.

3. Dosage and usage:

The usage and dosage of mitotane should be determined by a professional doctor based on the patient's specific conditions. Typically, patients receive a high dose of mitotane early in treatment and then taper to a maintenance dose. Usage is usually oral and can be taken with food to relieve gastrointestinal discomfort.

4. Side effects:

The use of mitotane may be associated with a variety of side effects, including but not limited to:

1.Nausea and vomiting;

2.Diarrhea;

3.Skin rash;

4.Fatigue;

5.Abnormal liver function.

Patients should pay close attention to these side effects while using mitotane and inform their doctor immediately if they feel unwell.

5. Warnings and precautions:

1.Patients should avoid driving or operating machinery while taking mitotane as it may cause drowsiness and affect concentration.

2.Mitotan may be harmful to pregnancy and should be avoided by pregnant women.

3.During the use of mitotane, patients need to regularly monitor liver function, blood and hormone levels to ensure the effectiveness and safety of treatment.

6. Contraindications:

1.Patients who are allergic to mitotane or any ingredient in the drug.

2.Pregnant and lactating women.

3.Patients with severe liver damage.

7. Drug interactions:

Patients should tell their doctors about all medications they are taking, including prescription drugs, over-the-counter drugs, and supplements. Drugs that may interact with mitotane include:

1.Other blood pressure lowering drugs;

2.Anticoagulant drugs;

3.Anti-epileptic drugs;

4.Ketoconazole drugs.

8. Medication for special groups:

1.Children: The administration and dosage of mitotane in children require special caution.

2.Geriatric: Elderly patients may require dosage adjustments because their kidney function may be reduced.

9. Listing and price situation:

Mitotane has not yet been launched in China, so patients cannot purchase it domestically and need to purchase it through overseas channels. There are original drugs and generic drugs abroad. The Turkish version of the original drug is about more than 7,000 yuan, followed by the European version of the original drug, which is about 9,000 yuan. There are also cost-effective generic drugs, mainly Laos and ASEAN generic drugs. The price is about more than 3,000 yuan. The ingredients of the original drugs and generic drugs are the same.