What are the side effects of Nivolumab?

The most common side effects of Nivolumab itself include fatigue, muscle and bone pain, diarrhea, rash, cough, nausea, itching, decreased appetite, joint pain, constipation, difficulty breathing, abdominal pain, nose and throat infections, fever, headache, anemia, and vomiting. Some negative effects are temporary and controllable. Some life-threatening adverse reactions require aggressive immunosuppressive treatment and permanent discontinuation.

The most common systems affected by nivolumabirAEs include the gastrointestinal and cutaneous systems, usually manifesting as pruritic rash, diarrhea, or colitis. When immune-mediated endocrine inflammation resolves, glandular function may be impaired, necessitating permanent hormone replacement. This includes nivolumab-induced hypothyroidism, hypopituitarism, adrenal insufficiency, and type 1 diabetes. Treatment options for serious and life-threatening irAEs include systemic corticosteroids. When necessary, prednisolone is administered at 1-2 mg/kg or intravenously to prevent gastric ulcers and osteoporosis at the same time. In steroid-refractory cases, additional immunosuppression is performed with drugs such as infliximab, mycophenolate mofetil, or cyclophosphamide.

The generic drug Nivolumab is currently on the market in China, but it has not yet been included in medical insurance. This drug is a strictly controlled drug, and its purchase channels are restricted. Specifications The price of each box of 40mg/4ml may be around RMB 4,000. The Turkish version of the nivolumab generic drug listed overseas may cost more than RMB 2,000 per box of 40mg/4ml (the price may fluctuate due to exchange rates). Currently, there is no generic version of nivolumab available on the market. For more drug information and specific prices, please consult a medical consultant.