How to take Zanubrutinib? Is it okay to take two pills a day?

Zanubrutinib (Zanubrutinib) is indicated for the treatment of mantle cell lymphoma (MC) who have received at least one prior therapy. L), Waldenstrom's macroglobulinemia, relapsed or refractory marginal zone lymphoma (MZL), chronic lymphocytic leukemia, or small lymphocytic lymphoma. Patients with marginal zone lymphoma may have received at least one anti-CD20-based regimen. Zanubrutinib is only available by prescription, and treatment should be initiated and supervised by a doctor experienced in the use of cancer drugs.

According to the prescribing information of zanubrutinib, the recommended dose is 160 mg orally twice daily or 320 mg orally once daily until disease progression or unacceptable toxicity occurs. The common capsule size of zanubrutinib is 80mg. It can be seen that patients can take two 160mg capsules a day, swallow the whole capsule with water, and do not open, break or chew the capsule. If you experience serious side effects while taking zanubrutinib, your doctor may decide to interrupt and reduce the dose or stop treatment. The recommended dose for patients with severe hepatic impairment is 80 mg orally twice daily. When coadministered with strong CYP3A inhibitors, reduce the dose to 80 mg orally once daily; when coadministered with moderate CYP3A inhibitors, reduce the dose to 80 mg orally twice daily; avoid coadministration with strong CYP3A inducers; also avoid coadministration with moderate CYP3A inducers, and if unavoidable, increase the dose to 320 mg orally twice daily.

The original drug of zanubrutinib has been launched in China and has been included in the medical insurance. The price of 80mg*64 capsules per box may be around 6,000 yuan. The original drug of zanubrutinib marketed overseas is relatively expensive. There are currently no generic drugs of zanubrutinib on the market.