What should I do if the side effects of Zanubrutinib are too great?

If patients experience serious side effects while taking zanubrutinib (Zanubrutinib), patients should tell their doctor immediately about the side effects and symptoms they are experiencing. This may include any unusual experiences such as persistent discomfort, difficulty breathing, heart problems, abnormal liver function, bleeding tendencies, etc.

Common side effects of zanubrutinib include neutropenia, upper respiratory tract infection, bleeding, bruising, rash, and musculoskeletal pain; the most common serious side effects are neutropenia, pneumonia, hypertension, and thrombocytopenia. In clinical studies of zanubrutinib, warnings and precautions such as bleeding, infection, cytopenias, second primary malignant tumors, arrhythmias, embryo-fetal toxicity, etc. have also emerged.

Your doctor may consider adjusting the dose of zanubrutinib or suspending treatment to reduce side effects. Based on the patient's specific situation, the doctor can develop an individualized treatment plan to ensure the patient's safety and comfort; For patients with severe liver damage, it is recommended to reduce the dose to 80mg twice daily orally. For specific side effects, doctors can give symptomatic treatment to relieve discomfort. For example, nausea medications may be considered if the patient experiences nausea or vomiting, and topical or allergy medications may be considered if skin reactions occur. Asymptomatic lymphocytosis should not be considered an adverse reaction, and these patients should continue taking zanubrutinib.

The original drug of zanubrutinib has been launched in China and has been included in the medical insurance. The price of 80mg*64 capsules per box may be around 6,000 yuan. The original drug of zanubrutinib marketed overseas is relatively expensive. There are currently no generic drugs of zanubrutinib on the market.