Where to buy Zanubrutinib cheaply

Zanubrutinib, sold under the brand nameBrukinsa, is an anticancer drug used to treat mantle cell lymphoma (MCL), Waldenströ macroglobulinemia (WM), marginal zone lymphoma (MZL) and chronic lymphocytic leukemia (CLL). Zanubrutinib is classified as a Bruton's tyrosine kinase (BTK) inhibitor and is administered orally after marketing. It was approved for medical use in the United States in November 2019.

Bruton's tyrosine kinase (BTK) is a non-receptor kinase and a signaling molecule for B cell receptors expressed on the surface of peripheral B cells. The BCR signaling pathway plays a critical role in normal B cell development as well as the proliferation and survival of malignant B cells in many B cell malignancies, including mantle cell lymphoma (MCL). Zabrutinib inhibits BTK by forming a covalent bond with cysteine u200bu200b481 residue in BTK's adenosine triphosphate (ATP) binding pocket, which is the active site of the enzyme. By blocking the BCR signaling pathway, zanubrutinib inhibits the proliferation, trafficking, chemotaxis and adhesion of malignant B cells, ultimately leading to a reduction in tumor size. Zanubrutinib has also been shown to downregulate the expression of programmed death ligand 1 (PD-1) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) on CD4+ T cells.

The original drug of zanubrutinib has been launched in China and has been included in the medical insurance. The price of 80mg*64 capsules per box may be around 6,000 yuan. The original drug of zanubrutinib marketed overseas is relatively expensive. There are currently no generic drugs of zanubrutinib on the market.