How much does a bottle of Vandetanib cost?

Vandetanib is a once-daily oral tyrosine kinase inhibitor that works by blocking RET (rearranged during transfection), vascular endothelial growth factor receptors (VEGFR-2, VEGFR-3) and epidermal growth factor receptors, and to a lesser extent VEGFR-1, which are important targets in thyroid cancer (TC). Vandetanib is a potentially effective option for the treatment of advanced medullary thyroid carcinoma (MTC) and dedifferentiated papillary thyroid carcinoma unresponsive to radioactive iodine. The most important role of vandetanib in aggressive disease is to prolong progression-free survival and stabilize disease.

The ZETA trial confirmed the clinical efficacy of vandetanib in patients with sporadic advanced medullary thyroid carcinoma tumors harboring the M918T mutation. Obvious side effects were observed during treatment, such as fatigue, hypertension, QTc prolongation, rash, hand-foot syndrome, diarrhea, etc. Serious side effects may require suspension of medication. During long-term treatment of patients with vandetanib, the efficacy of vandetanib may be overcome by resistance to the drug. However, the effectiveness of the treatment could be improved by molecular characterization of the tumors and the possibility to test the sensitivity of primary thyroid cancer cells from each subject to different tyrosine kinase inhibitors.

The original drug vandetanib has not yet been marketed in China, so it is not included in medical insurance. The original drug specifications of vandetanib listed overseasThe price of each box of 300mg*30 tablets may be more than 30,000 yuan (the price may fluctuate due to the exchange rate). There is currently no generic drug of vandetanib produced and launched. For more drug information and specific prices, please consult the medical consultant of Yaode.