Aducanumab Chinese instructions

1. Indications:

Aducanumab is a drug used to treat Alzheimer's disease. Alzheimer's disease is a progressive neurological disease that usually occurs in older adults and is characterized by cognitive impairment, memory loss, and impairment of daily living abilities.

2. Mechanism of action:

Aducanumab is an antibody drug whose mechanism of action involves clearing βamyloid plaques (beta-amyloid plaques) in the brain. These plaques accumulate in the brains of people with Alzheimer's disease and are thought to be involved in the progression of the disease and neurodegeneration. Aducanumab slows the progression of the disease by binding to and clearing these plaques.

3. Pharmacology:

Aducanumab is highly specific and can selectively bind to β amyloid plaques and reduce their accumulation in the brain. This is expected to reduce patients' symptoms of cognitive impairment and improve their quality of life. Pharmacological studies are also further elucidating the mechanism by which aducanumab distributes and clears βamyloid plaques in the brain.

4. Dosage and usage:

1.Initial dosage: 1 time per month, 10mg/kg body weight;

2.Dose escalation: During the first 6 months of treatment, gradually increase the dose every month, up to a maximum of no more than 10mg/kg body weight each time;

3.Treatment timing: Treatment with aducanumab should be started early to help slow down the progression of the disease to the greatest extent.

5. Side effects:

Aducanumab may cause some adverse reactions, including but not limited to:

1.Skin reaction: skin redness, swelling, itching or rash may occur

2.Headache: Some patients may experience headache

3.Nausea: Symptoms of nausea and vomiting may also occur

4.Cerebral hemorrhage: In some cases, cerebral hemorrhage may occur, especially in patients with risk factors for bleeding

6. Warnings and precautions:

Be aware of the following warnings and precautions when using aducanumab:

1.For the risk of cerebral hemorrhage: Patients need to be closely monitored for the risk of cerebral hemorrhage while taking aducanumab, especially for those with a history of cerebrovascular disease.

2.Allergic reaction: If severe allergic reaction occurs, including shortness of breath, hives, throat swelling, etc., you should stop using the drug immediately.

3.Hypertension: Drugs may cause high blood pressure, and patients need to monitor their blood pressure regularly.

7. Contraindications:

Contraindications to aducanumab include:

1.Patients who are allergic to drug ingredients

2.Patients with a history of severe cerebrovascular disease

3.Pregnant and lactating women

8. Drug interactions:

It is not known how aducanumab interacts with other drugs. Patients should tell their doctor about all prescription drugs, over-the-counter drugs, and supplements they are using before using this medication.

9. Medicine for special groups:

1.Children: The safety and effectiveness of aducanumab have not been established in children and therefore its use in the treatment of children is not recommended.

2.Elderly: Aducanumab is mainly used to treat Alzheimer’s disease in the elderly, but it should be used with caution based on the patient’s overall health and potential risks.

3.Pregnant and lactating women: Use of aducanumab during pregnancy may cause risks to the fetus and is not recommended for pregnant women. At the same time, it is not recommended for breastfeeding women.

The use of aducanumab needs to be under the guidance of a doctor and adjusted according to the patient's specific situation and needs. Patients and doctors should work closely together to ensure proper use of medications and maximum effectiveness. If any unclear symptoms or discomfort occur, patients should consult their doctor immediately. This Chinese instruction manual is for reference only. Specific medication information should be based on the doctor's advice.