How much does a box of Venetoclax tablets cost?

Venetoclax is indicated for the treatment of adults with chronic lymphocytic leukemia or small lymphocytic lymphoma, in combination with azacitidine, decitabine, or low-dose cytarabine for the treatment of adults 75 years of age or older with newly diagnosed acute myeloid leukemia or who have comorbidities that preclude the use of intensive induction chemotherapy.

Veneclar kills cancer cells by inhibitingBCL-2, a group of proteins that regulate cell death by inhibiting or inducing apoptosis. Apoptosis is an ordered form of cell death in which cellular contents are "packaged" for collection by immune cells. This is different from the way cells die due to injury. In some cancers, including chronic lymphocytic leukemia and acute myeloid leukemia, there is large amounts of BCL-2 on the surface of cells. This overexpression of BCL-2 allows tumor cells to survive longer and is associated with resistance to chemotherapy. Laboratory studies have shown that venetoclax binds to this protein and kills cancerous lymphocytes in chronic lymphocytic leukemia and acute myeloid leukemia.

The original drug of Venacla is already on the market in China, and can be found in the Category B medical insurance directory. The specification is 100mg*14 tablets and the price per box may be around RMB 5,000. The Turkish version of Venaclaoriginal drug, specifications100mg*112 tablets, sold overseas, costs around RMB 10,000 per box (the price may fluctuate due to exchange rates), which is even more expensive. Cheaper generic drugs are also sold overseas, and their pharmaceutical ingredients are basically the same as those of the original drugs. The price of a box of 100mg*120 tablets produced by a Bangladeshi pharmaceutical factory is around RMB 4,000 (prices may fluctuate due to exchange rates).