What medicine is Vismodegib?

Vismodegib capsules are a prescription medicine used to treat adults with a type of skin cancer called basal cell carcinoma (BCC) that has spread to other parts of the body, has come back after surgery, or has been deemed untreatable by doctors with surgery or radiation. It's unclear whether Vimodegib is safe and effective in children.

Basal cell carcinoma is a type of skin cancer that occurs when the basal cells on the top layer of your skin overproduce. Vimodegib is a selective Hedgehog pathway inhibitor that binds to and competitively inhibits SMO. Inhibition of SMO causes the transcription factors GLI1 and GLI2 to remain inactive; this prevents the expression of tumor-mediating genes in the Hedgehog pathway. VimodegibA drug that can treat basal cell carcinoma by stopping cancer cells from growing. In basal cell carcinoma, mutations in the Hedgehog pathway can lead to unrestricted proliferation of basal cells; this pathway is associated with more than 90% of basal cell carcinoma cases. One of the mechanisms involved in tumorigenesis involves ligand-independent pathway activation of SMO.

The original drug of Vimodegib is not currently on the market in the country, so it cannot be included in medical insurance. Overseas, Vimodegiboriginal drug has Turkish version and European version, specificationsThe price of 150mg*28 capsules per box may be around RMB 10,000-30,000 (the price may fluctuate due to the exchange rate). The price is very expensive, and there are currently no generic versions of Vimodegib. For more drug information and specific prices, please consult Yaodei Medical Consultants.