Where to buy Vemurafenib

Vemurafenib (Vemurafenib) is a low molecular weight molecule used to inhibit the mutated serine-threonine kinase BRAF. It selectively binds to the ATP-binding site of BRAF V600E kinase and inhibits its activity. Vemurafenib's biochemical affinity for mutant BRAF translates into potent inhibition of ERK phosphorylation and cell proliferation, only in BRAF mutant cell lines.

In animal model experiments, it was confirmed that vemurafenib achieved tumor regression in cells containingBRAF V600E mutation. Clinical trials of vemurafenib in patients with stage I, II, and III unresectable metastatic melanoma harboring the BRAF V600E mutation have shown high objective response rates between 50% and 80%. The median progression-free survival was extended from 2 months in the dacarbazine group to 7 months in the vemurafenib group, and the median overall survival was extended from 9 months to 14 months, respectively. A major problem is that most patients develop resistance to vemurafenib treatment after several months, and multiple resistance mechanisms have been described. Approximately 25% of patients under vemurafenib developed keratoacanthoma-type cutaneous squamous cell carcinoma, which has low invasive potential and does not metastasize. The drug was generally tolerated very well, with many patients receiving treatment long-term.

Vemurafenib The original drug has been launched in China and has entered the scope of medical insurance. Specification The price of 240mg*56 tablets per box may be around 7,000 yuan, which is very expensive. This drug may be sold in domestic hospitals or pharmacies. The Turkish version of Vemurafenib Original drug listed overseas, specifications240mg*56 tablets, may cost more than 2,000 yuan per box (the price may fluctuate due to exchange rates), which is relatively cheap. There is currently no generic version of Vemurafenib on the market. For more drug information and specific prices, please consult a medical consultant.