How much does Tisotumab vedotin-tftv cost?

Vedotin - Tisotumab vedotin-tftv is an injectable preparation used to treat cervical cancer (cancer that starts at the opening of the uterus) that does not improve or comes back after treatment with other drugs, or has spread to other parts of the body. Vitin-Tisotuzumab belongs to a class of drugs called antibody-drug conjugates, which work by killing cancer cells.

Vitin-Tisotuzumab is a tissue factor-directed antibody-drug conjugate (ADC) composed of an anti-tissue factor (TF) human IgG 1-κ antibody via a protease-cleavable valine-citrulline linker with the microtubule-disrupting agent monomethyl auristatin E (MMAE) conjugated. Vitin-Tisotuzumab is the first TF-directed ADC that acts by binding to TF expressed on solid tumors. TF plays a key role in tumor-associated angiogenesis, progression, and tumor survival and metastasis. TF is a novel target in cancer because it is commonly overexpressed in solid tumors, including cervical cancer, and is associated with adverse clinical outcomes. Vitin-Tisotuzumab targets TF-expressing cells to deliver MMAE, thereby inducing direct cytotoxicity and bystander killing of neighboring cells.

Vitin-TisotumabThe original drug has not yet been marketed in China, so it cannot be included in medical insurance. The original drugs marketed overseas are very expensive. The price of each box of 40 mg/vial may be around RMB 90,000 (the price may fluctuate due to the exchange rate). Currently, there is no generic version of Vitin-Tisotuzumab on the market. For more drug information and specific prices, please consult the medical consultant of the drug.