Trifluridine Tipiracil Tablets (Lonsurf) Medicare Prices 2023

Trifluridine (Lonsurf) is a medicine used to treat adults with colorectal cancer (cancer of the large intestine) and metastatic stomach cancer (which has spread to other parts of the body). It is used in patients who have received or cannot receive other treatments for the cancer. It can be used in combination with bevacizumab, another cancer drug, to treat colorectal cancer. Trifluridine and tipiracil tablets contain the active substances trifluridine and tipiracil.

In the body, trifluridine is converted into its active form and integrated into the cell's genetic material, DNA. Therefore, trifluridine interferes with DNA function, preventing cells from dividing to create more cells. Trifluridine is more easily converted to its active form in cancer cells than in normal cells, resulting in higher levels of the active form of the drug and a longer lasting effect in cancer cells. This reduces the growth of cancer cells, while normal cells are only slightly affected. Tipiracil increases the levels of trifluridine in the blood by slowing its breakdown, which enhances the effects of trifluridine.

TrifluridineThe original drug of tipiracil tablets has been marketed in China under the trade name Langsif, but it has not yet been covered by medical insurance. Patients can only purchase this drug at their own expense. The price of 15mg*20 tablets per box may be around 6,000 yuan. The price of the Hong Kong version of 15mg*20 tablets per box may be more than 10,000 yuan (the price may fluctuate due to the exchange rate).

The Japanese version of trifluridine tipiracil tablets, original drug, specifications 20mg*20 tablets, may be priced around RMB 5,000 per box per box (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine tipiracil tablets overseas, whose pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of a box of 15mg*20 tablets produced by an Indian pharmaceutical factory may be around RMB 1,000 (the price may fluctuate due to exchange rates).